Self-organization of the in vitro attached human embryo
Gist F. Croft
Lauren N. Pietila
Eric D. Siggia
Ali H. Brivanlou
In this study led by Ali Brivanlou of Rockefeller University, scientists report the development of an in vitro “attachment platform”: a system that allows the study of the post-implantation development phase of the human embryo. In this arrangement, human blastocysts self-organize to display key events of development that occur in vivo. This novel method builds upon a previous study reported in mice. Deglincerti and colleagues point to key developmental differences between human and mouse embryos, a species-specificity that emphasizes the need to study human embryos to answer questions about human development. This study raises the prospect of studying human embryos in vitro beyond the 14-day rule’s two-week limit.